Tesofensine is a cutting-edge compound that offers a unique and clinically backed approach to weight loss by targeting the brain’s appetite and energy regulation centers. It works as a triple monoamine reuptake inhibitor, increasing levels of dopamine, norepinephrine, and serotonin—neurotransmitters responsible for mood, motivation, and appetite control.
This multi-action mechanism helps reduce food cravings, enhance satiety, and boost energy expenditure—making it a powerful tool for individuals struggling with weight loss resistance, low motivation, or emotional eating.
Originally developed for neurodegenerative disorders like Parkinson’s and Alzheimer’s, Tesofensine was later found to produce significant weight loss effects in clinical trials, with participants losing up to 10% of body weight in just a few months.
Suppresses appetite and reduces cravings
Enhances metabolism and energy output
Supports mood, focus, and motivation
Helps overcome weight loss plateaus
Complements GLP-1s or other fat-loss strategies
Tesofensine is ideal for those seeking a brain-body approach to weight management—targeting not just calories, but the why behind hunger and habits.