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US-Licensed Medical Providers & Pharmacies
Tri-Mix Injection

CA Therapies

Sexual Health

Key Benefits:
than oral ED meds
and sex drive
than oral ED meds

Penile Injections


Subcutaneous injection

10-30 Doses

Requires telehealth consult


Tri-mix is faster, more effective and has less side-effects than Viagra & is commonly prescribed as a safer alternative treatment of male erectile dysfunction (ED).


Tri-Mix

Brent Agin MD

03/15/2024 5:12PM

Tri-mix is faster, more effective and has less side-effects than Viagra & is commonly prescribed as a safer alternative treatment of male erectile dysfunction (ED).  

Tri-mix is administered as a penile self-injection, typically considered to be the most powerful class of anti-erectile dysfunction agents.

Research has found that these drugs can induce a penile erection when injected directly into the penis. Since 1983, these erectile dysfunction injections have gained popularity and acceptance. The FDA approved Prostaglandin E1 for treatment in 1995 and then eventually papaverine and phentolamine were added to make the Tri-mix. 

The thought of injecting a drug into your penis may sound intimidating, but research has shown that more than 70% of men are highly satisfied with this therapy. If you are not getting results from the conventional medications such as Viagra® and Cialis®, penile injections are now considered the go to treatment. When properly administered, Tri-Mix can be an effective, safe and life changing medication. 

Safety Information

Important Information:

Do not take this medicine with any of the following conditions: hypersensitivity or allergy to any component of this formulation conditions predisposing you to priapism (painful erection lasting 4 hours or more) sickle cell anemia, multiple myeloma or leukemia anatomical deformation of the penis or penile implants direction by your physician that sexual activity is inadvisable or contraindicated. Tell your doctor if you have a condition or are taking a medicine that interferes with blood clotting. Adverse reactions and potential side effects: Mild to moderate pain during injection painful sensation with erection small amount of bleeding at the injection site. Call your healthcare provider if you notice any redness, lumps, swelling, tenderness or curvature of the erect penis. If you experience an erection lasting more than 2 hours, you may take 2 - 4 pseudoephedrine 30 mg by mouth once and apply an ice pack. If your erection does not go away within the next hour, seek professional help immediately. Erections that last more than 6 hours can cause serious damage to the penile tissue.

Product Supplies:

31g x 5/16" 1ccc syringe - 30 Alcohol wipes - 30 Mix kit - 1

Ingredients:

Papaverine HCL 30mg, Phentolamine Mesylate 1mg and Prostaglandin E1 (Alprostadil for some CA scripts) 10mcg per mL

F.A.Q.

Tri-Mix should not be taken more often than twice a week with at least 24 hours in between doses.

Start your dosage low and slow, it may take several attempts to find your right dosage. This is a rare side effect that usually occurs from injecting too much medication. Option 1: Take Sudafed (Pseudophedrine 30mg, purchased at the pharmacy counter). If you experience an erection lasting more than 3 hours, you may take 4 Sudafed 30mg by mouth once and apply an ice pack between your legs at 20 minute intervals. Option 2: Inject Phenylephrine HCI, an injectable antidote available with your prescription. Follow instructions included with the vial. If your erection still does not start to go down within 1 hour after the injection of Phenylephrine HCl, then take pictures of all your medications and go to the emergency room.

Tri-Mix should produce an erection within 5 to 20 minutes after injection and typically lasts up to one hour.
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