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US-Licensed Medical Providers & Pharmacies
Super Quad-Mix Injection

Sexual Health

Key Benefits:
than oral ED meds
and sex drive
than oral ED meds

Penile Injections


Subcutaneous injection

10-30 Doses

Requires telehealth consult

Not available in CA or WI


Super Quad-mix is is a penile self-injection commonly prescribed for treatment of male erectile dysfunction (ED).  Quad-mix contains four drugs from complimentary classes designed to act synergistically, mixed into a sterile injection.


Super Quad-Mix

Brent Agin MD

03/13/2024 6:33PM

Quad-mix is is a penile self-injection commonly prescribed for treatment of male erectile dysfunction (ED).  Quad-mix contains four drugs from complimentary classes designed to act synergistically, mixed into a sterile injection.  

Super quad-mix is administered as a penile self-injection, typically considered to be the most powerful class of anti-erectile dysfunction agents.

Research has found that these drugs can induce a penile erection when injected directly into the penis. Since 1983, these erectile dysfunction injections have gained popularity and acceptance. The FDA approved Prostaglandin E1 for treatment in 1995 and then eventually papaverine, phentolamine and atropine were added to make the Quad-mix. Most men begin penile injection therapy trying Tri-Mix or Quad-Mix, but if these are not producing a satisfactory erection then you can move to Super Quad-mix, which contains higher strengths of the drugs in Quad-mix. 

The thought of injecting a drug into your penis may sound intimidating, but research has shown that more than 70% of men are highly satisfied with this therapy. If you are not getting results from the conventional medications such as Viagra® and Cialis®, penile injections are now considered the go to treatment. When properly administered, Super Quad-Mix can be an effective, safe and life changing medication.   

Safety Information

Important Information:

Reasons not to take this medicine: Do not take this medicine if you have hypersensitivity or allergy to any component of this formulation conditions predisposing you to priapism (painful erection lasting 4 hours or more): sickle cell anemia, multiple myeloma or leukemia anatomical deformation of the penis or penile implants direction by your physician that sexual activity is inadvisable or contraindicated. Tell your doctor if you have a condition or are taking a medicine that interferes with blood clotting. Adverse reactions and potential side effects Mild to moderate pain during injection painful sensation with erection small amount of bleeding at the injection site. Call your healthcare provider if you notice any redness, lumps, swelling, tenderness or curvature of the erect penis. If you experience an erection lasting more than 2 hours, you may take 2 - 4 pseudoephedrine 30 mg by mouth once and apply an ice pack. If your erection does not go away within the next hour, seek professional help immediately. Erections that last more than 6 hours can cause serious damage to the penile tissue.

Product Supplies:

31g x 5/16" 1cc syringe - 30 Alcohol wipes - 30 Mix kit - 1

Ingredients:

papaverine HCL 30mg, Phentolamine Mesylate 4mg, Prostaglandin E1 40mcg, and atropine 400mcg per mL

F.A.Q.

Super Quad-Mix should not be taken more often than twice a week with at least 24 hours in between doses.

Start your dosage low and slow, it may take several attempts to find your right dosage. This is a rare side effect that usually occurs from injecting too much medication. Option 1: Take Sudafed (Pseudophedrine 30mg, purchased at the pharmacy counter). If you experience an erection lasting more than 3 hours, you may take 4 Sudafed 30mg by mouth once and apply an ice pack between your legs at 20 minute intervals. Option 2: Inject Phenylephrine HCI, an injectable antidote available with your prescription. Follow instructions included with the vial. If your erection still does not start to go down within 1 hour after the injection of Phenylephrine HCl, then take pictures of all your medications and go to the emergency room.

Super Quad-Mix should produce an erection within 5 to 20 minutes after injection and typically lasts up to one hour.
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