Similar to Semaglutide, Tirzepatide works by increasing insulin sensitivity, improving glucose metabolism and decreasing appetite. 

Tirzepatide vs. Semaglutide

Tirzepatide and Semaglutide are medications in the same class and have both been approved for the treatment of type 2 diabetes. Semaglutide has recently been FDA approved for the treatment of weight management, while Tirzepatide has received Fast Track designation.   

Tirzepatide has a unique, dual action approach with both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist properties. This combination of actions is thought to have a greater impact on weight loss compared to Semaglutide, which only affects the GLP-1 receptor.  

Some studies have shown Tirzepatide to be more effective in promoting weight loss than Semaglutide, with one study showing patients lost an average of 14.9% of their body weight on Tirzepatide while others on Semaglutide lost an average of 10.4%. 

Tips for Taking Tirzepatide: You can take Tirzepatide with or without food. If you need to change the day of the week, you may do so if your last dose of Tirzepatide was given 2 or more days before. What to Do if You Miss a Dose: If you miss a dose of Tirzepatide and the next scheduled dose is more than 2 days away (>48 hours), take the missed dose as soon as possible. If you miss a dose of Tirzepatide and the next scheduled dose is less than 2 days away (<48 hours), do not administer the dose. Take your next dose on the regularly scheduled day. Who Should NOT Take Tirzepatide: If you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). If you have had a serious allergic reaction to Tirzepatide.