HCG can be used alone or along with testosterone replacement therapy (TRT) for hormone optimization in male patients.  

HCG, also known as Human Chorionic Gonadotropin, has been safely used for more than 50 years. HCG has specific and well-documented effects on the body as demonstrated during pregnancy and fertility treatments, which is why this hormone's effects have been found to help with hormone balancing. HCG works by mimicking luteinizing hormone (LH), which is naturally produced in both men and women. LH is produced and released by cells in the anterior pituitary gland and is crucial in regulating the function of the testicles in men and ovaries in women.  

Depending on your age or current medical situation, HCG can be used alone or along with testosterone replacement therapy (TRT) for hormone optimizing. If one’s testicles are still capable of producing testosterone HCG can help improve the signaling to the testicles and potentially stimulate them to produce and release higher amounts of testosterone. This can be a good option for those with low testosterone that are under the age of 45 and still interested in fertility.   

When TRT is used alone it can lower testosterone and sperm production. This is because there can be too much circulating testosterone so the brain will stop signaling the testicles to make and release natural testosterone.  Using HCG helps preserve sperm production by maintaining intra-testicular testosterone levels and can reduce testicular shrinkage that can occur with TRT alone.    

Studies have shown that in men with testosterone levels within normal range that elected for TRT to optimize levels found their own testicular testosterone production dropped by 94% while being treated. The same group of men who received HCG injections simultaneously with TRT saw their testicular testosterone production increase by up to 26% from baseline.  

Furthermore, the American Urological Association, has found HCG appropriate for those men with non-optimal testosterone levels who also desire to maintain fertility.