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Vardenafil / Phentolamine


US-licensed medical health professionals
Erectile dysfunction
Delays premature ejaculation

Premature ejaculation (PE) also known as rapid injection is when ejaculation happens sooner than a man or his partner would like during sex. About 1 in 3 men 18 to 59 years old have problems with PE and it can be a problem for both you and your partner.

Premature ejaculation was thought to be entirely psychological, however, it is now thought that some men may have a chemical imbalance of important neurotransmitters like serotonin, which can lead to other psychological sexual dysfunction, such as performance anxiety.

PE can be frustrating especially if it causes sex to be less enjoyable, impacts your relationship or lowers your self-confidence. If it happens often and becomes a problem, there are therapies that can help.



  • Vardenafil is classified as a phosphodiesterase type 5 inhibitor (PDE5 inhibitor) and helps to increase blood flow while relaxing muscles and blood vessels.
  • Phentolamine causes blood vessels to widen, which increases blood flow.    


Behavioral Therapy

Behavioral therapy uses exercises to help build tolerance to delay ejaculation. The goal is to help you train your body away from PE. Some choices are the squeeze method and the stop-start method. Exercises work well, but they may not be a lasting answer.

  • Kegel exercises – exercises designed to strengthen the pelvic floor.
  • Squeeze Method - when close to orgasm, you or your partner firmly squeeze your penis, so your erection partly goes away stopping ejaculation.
  • Stop-Start Method - when close to orgasm, you or your partner stops until the urge to orgasm dissipates and then restarts sex. This takes patience but can be effective.
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