Erectile Dysfunction Injections

Papaverine is particularly known as a smooth muscle relaxant and vasodilator. Its principle pharmacological action is as a non-specific vasdilator of the arterioles and capillaries. Major side-effects include priapism and corporal fibrosis. These side-effects are greatly reduced when papaverine is used in very low dosages and combined with phentolamine and alprostadil.

Phentolamine may provoke a reflex, increasing sympathetic outflow and the release of norepinephrine. When phentolamine is used for the treatment of ED, it is often used in combination with other agents (e.g. papaverine) to enhance its efficacy. The combination of phentolamine and papaverine for the treatment of ED has been studied extensively. This combination can be efficacious and may induce erections sufficient for sexual intercourse in over 90% of cases.

Alprostadil (Prostaglandin E1) binds with PGE receptors, and the resultant relaxation response in the smooth muscle is mediated by cAMP. Little is known about the pharmacokinetics of PGE1 but it is believed that as much as 80% may be metabolized in one pass through the lungs. In all probability, this rapid degradation by the lungs accounts for its lack of any significant cardiovascular system side-effects when administered intracavernosally. It can also be metabolized in the penis. Alprostadil has also been used in combination with other agents, such as papaverine, and the combination was superior to only alprostadil.  Alprostadil is available as an intraurethral pellet (MUSE),  intraurethral gel with penetration enhancers , or intracavernosal injection. Numerous studies show that the injection is more efficacious.

Atropine is a non-selective muscarine agonist that functions by competitively binding to muscarine receptors, a class of acetylcholine receptor involved in the contraction and relaxation of smooth muscle and epithelial tissue throughout various parts of the body. These receptors, when activated locally in the penis by acetylcholine molecules, cause the corpus cavernosum to contract–by inhibiting the absorption of acetylcholine by these receptors into cells in the vasculature of the penis, Atropine effectively relaxes the vessels in the penis and helps in achieving erection. While atropine’s efficacy when used alone is relatively insignificant and it’s use in combination with other injectables does not improve the success rates of a mixture without atropine, it can help reduce the pain PGE1 can cause.

Ingredients:

Ingredients vary per injection.  See individual product for details.

Erectile Dysfunction Injections

   $159.95 – $324.95

*This Nutrient Injection is only available with a Wellness Consultation. During your consultation with the medical provider, discuss the plan that best suits your goals today!

Requires a Wellness Consultation

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